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Breastfeeding & Digestive Enzymes: The Important Ones and Information on Supplements

Digestive enzymes are a vital part of proper nutrient absorption. They break down protein, carbs, and fats into smaller components that are transported for energy. These enzymes are released in different parts of the body and are triggered by various stages of digestion. [1]

Lacking specific enzymes in the body can lead to improper digestion, causing issues such as lactose intolerance. [2] Many will look to digestive enzyme supplements in hopes of relieving their baby's food allergy and intolerance symptoms.

Here, we dig into the science behind whether supplementation can truly make that kind of impact.

Important Types of Digestive Enzymes In Our Body

There are three main enzymes used in the digestive process for both babies and adults. We’re going to look into the purpose of each, different types, where they’re found, and the type of medical test to check enzyme levels.


  • Purpose: Break down protein into amino acids and peptides.

  • Types: Pepsin, trypsin, chymotrypsin, carboxypeptidase A & B.

  • Where: Secreted by the stomach and pancreas.

  • Test: Blood analysis.

Natural Sources: Pineapples, papaya, raw honey, kefir, kimchi, miso, kiwi, & ginger.


  • Purpose: Break down carbs into simple sugars.

  • Types: Maltase, lactase, sucrase.

  • Where: Secreted by salivary glands, pancreas, and/or small intestine.

  • Test: Amylase blood levels can detect various pancreas diseases. Lactase and maltase issues can be detected through a hydrogen breath test. Sucrose intolerance is tested via small intestine biopsy.

Natural Sources: Mango, raw honey, banana, kimchi, & miso.


  • Purpose: Break down fat into three fatty acids and glycerol.

  • Types: Pancreatic lipase (PL) and pancreatic lipase-related protein 2 (PLRP2).

  • Where: Pancreas & digestive “juice.”

  • Test: Blood tests for lipase can help diagnose pancreas disorders.

Natural Sources: Avocado, kefir, kimchi, & miso.

Prescription Digestive Enzymes

Most prescriptions contain pancrelipase, a combination of all lipase, amylase, and protease. These pills have a specialized outer coating made to survive passing through stomach acid and release the contents after reaching the small intestine. [3]

The enzymes commonly originate from that made from pig pancreas which is regulated by the FDA. This means that as a medication there are proven clinical trials associated with the efficacy of the product. [4]

Digestive Enzyme Supplements

Digestive enzyme supplements are also available over the counter in liquid, powder, and pill form. These may come from plants or animals. They are not regulated by the FDA, there is little proof as to exactly how much enzyme they contain or if they will survive stomach acid to reach the intestine. [5]

Non-prescription lactase and alpha-galactosidase which assist with cow’s milk and bean sugar breakdown have been shown to help assist in digestion discomfort and associated symptoms.

Breastfeeding and Food Intolerances

Infants with food allergies or intolerances are most likely reacting to proteins transferred from the diet to breast milk. [6] If you’re unsure if your little is reacting to your milk, read our blog, What You Need to Know About Infant Food Allergies.

Since this is a protein reaction, a big question among families is whether protease digestive enzyme supplements will help break down the protein before it enters breast milk. Unfortunately, there is not any research specifically looking at digestive enzyme impacts on breast milk contents. However, researchers have tested the efficiency of specific protein breakdown in the gut which can still help guide our decision to use the supplements.

What The Research Says About Commercially Available Digestive Enzymes Versus Prescription

Research indicates that commercially available enzymes lacking the outer coating will not make it past the stomach to be effective in assisting digestion in the intestine. Therefore, suspensions and pills without what is called an “enteric coat” are not effective due to degradation.

Prescription enzymes are derived from pigs because their enzymes most closely match those found in humans. Prescription protease concentrations typically range from 50,000-100,000 USP units while the concentration for supplements, especially those derived from plants, are often under 5,000 USP.